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ECS(ASB2) mediates MLL degradation during hematopoietic differentiation

Mixed lineage leukemia (MLL) is a key epigenetic regulator of normal hematopoietic development and chromosomal translocations involving MLL are one of the most common genetic alterations in human leukemia. Here we show that ASB2, a component of the ECS(ASB) E3 ubiquitin ligase complex, mediates MLL...

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Bibliografski detalji
Glavni autori: Wang, Jingya, Muntean, Andrew G., Hess, Jay L.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277351/
https://ncbi.nlm.nih.gov/pubmed/22174154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-06-362079
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