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ECS(ASB2) mediates MLL degradation during hematopoietic differentiation
Mixed lineage leukemia (MLL) is a key epigenetic regulator of normal hematopoietic development and chromosomal translocations involving MLL are one of the most common genetic alterations in human leukemia. Here we show that ASB2, a component of the ECS(ASB) E3 ubiquitin ligase complex, mediates MLL...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3277351/ https://ncbi.nlm.nih.gov/pubmed/22174154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-06-362079 |
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