Menin-MLL Inhibitors Reverse Oncogenic Activity of MLL Fusion Proteins in Leukemia

Translocations involving the Mixed Lineage Leukemia (MLL) gene result in human acute leukemias with very poor prognosis. The leukemogenic activity of MLL fusion proteins is critically dependent on their direct interaction with menin, a product of the MEN1 gene. Here, we present the first small molec...

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Detalhes bibliográficos
Main Authors: Grembecka, Jolanta, He, Shihan, Shi, Aibin, Purohit, Trupta, Muntean, Andrew G., Sorenson, Roderick J., Showalter, Hollis D., Murai, Marcelo, Belcher, Amalia, Hartley, Thomas, Hess, Jay L., Cierpicki, Tomasz
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401603/
https://ncbi.nlm.nih.gov/pubmed/22286128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.773
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