Molecular Basis of the Mixed Lineage Leukemia-Menin Interaction: IMPLICATIONS FOR TARGETING MIXED LINEAGE LEUKEMIAS

Chromosomal translocations targeting the mixed lineage leukemia (MLL) gene result in MLL fusion proteins that are found in aggressive human acute leukemias. Disruption of MLL by such translocations leads to overexpression of Hox genes, resulting in a blockage of hematopoietic differentiation that ul...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Grembecka, Jolanta, Belcher, Amalia M., Hartley, Thomas, Cierpicki, Tomasz
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2010
Ämnen:
Molecular Biophysics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003368/
https://ncbi.nlm.nih.gov/pubmed/20961854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.172783
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk