Molecular Basis of the Mixed Lineage Leukemia-Menin Interaction: IMPLICATIONS FOR TARGETING MIXED LINEAGE LEUKEMIAS

Chromosomal translocations targeting the mixed lineage leukemia (MLL) gene result in MLL fusion proteins that are found in aggressive human acute leukemias. Disruption of MLL by such translocations leads to overexpression of Hox genes, resulting in a blockage of hematopoietic differentiation that ul...

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Autores principales: Grembecka, Jolanta, Belcher, Amalia M., Hartley, Thomas, Cierpicki, Tomasz
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Molecular Biophysics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003368/
https://ncbi.nlm.nih.gov/pubmed/20961854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.172783
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