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Molecular Basis of the Mixed Lineage Leukemia-Menin Interaction: IMPLICATIONS FOR TARGETING MIXED LINEAGE LEUKEMIAS

Chromosomal translocations targeting the mixed lineage leukemia (MLL) gene result in MLL fusion proteins that are found in aggressive human acute leukemias. Disruption of MLL by such translocations leads to overexpression of Hox genes, resulting in a blockage of hematopoietic differentiation that ul...

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Detalhes bibliográficos
Main Authors: Grembecka, Jolanta, Belcher, Amalia M., Hartley, Thomas, Cierpicki, Tomasz
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003368/
https://ncbi.nlm.nih.gov/pubmed/20961854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.172783
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