Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein–Protein Interaction between Menin and Mixed Lineage Leukemia (MLL)

Development of potent small molecule inhibitors of protein–protein interactions with optimized druglike properties represents a challenging task in lead optimization process. Here, we report synthesis and structure-based optimization of new thienopyrimidine class of compounds, which block the protei...

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Gepubliceerd in:J Med Chem
Hoofdauteurs: Borkin, Dmitry, Pollock, Jonathan, Kempinska, Katarzyna, Purohit, Trupta, Li, Xiaoqin, Wen, Bo, Zhao, Ting, Miao, Hongzhi, Shukla, Shirish, He, Miao, Sun, Duxin, Cierpicki, Tomasz, Grembecka, Jolanta
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5092235/
https://ncbi.nlm.nih.gov/pubmed/26744767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01305
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