Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein–Protein Interaction between Menin and Mixed Lineage Leukemia (MLL)

Development of potent small molecule inhibitors of protein–protein interactions with optimized druglike properties represents a challenging task in lead optimization process. Here, we report synthesis and structure-based optimization of new thienopyrimidine class of compounds, which block the protei...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Borkin, Dmitry, Pollock, Jonathan, Kempinska, Katarzyna, Purohit, Trupta, Li, Xiaoqin, Wen, Bo, Zhao, Ting, Miao, Hongzhi, Shukla, Shirish, He, Miao, Sun, Duxin, Cierpicki, Tomasz, Grembecka, Jolanta
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5092235/
https://ncbi.nlm.nih.gov/pubmed/26744767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01305
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