Pharmacologic inhibition of the menin-MLL interaction leads to transcriptional repression of PEG10 and blocks hepatocellular carcinoma

Hepatocellular carcinoma (HCC) accounts for ~85% of malignant liver tumors and results in 600,000 deaths each year, emphasizing the need for new therapies. Upregulation of menin was reported in HCC patients and high levels of menin correlate with poor patient prognosis. The protein-protein interacti...

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Veröffentlicht in:Mol Cancer Ther
Hauptverfasser: Kempinska, Katarzyna, Malik, Bhavna, Borkin, Dmitry, Klossowski, Szymon, Shukla, Shirish, Miao, Hongzhi, Wang, Jingya, Cierpicki, Tomasz, Grembecka, Jolanta
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752584/
https://ncbi.nlm.nih.gov/pubmed/29142068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-0580
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