The complexity of blocking bivalent protein-protein interactions: development of a highly potent inhibitor of the menin-Mixed Lineage Leukemia (MLL) interaction

The protein-protein interaction between menin and Mixed Lineage Leukemia 1 (MLL1) plays an important role in development of acute leukemia with translocations of the MLL1 gene and in solid tumors. Here, we report the development of a new generation of menin-MLL1 inhibitors identified by structure-ba...

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Publicado en:J Med Chem
Main Authors: Borkin, Dmitry, Klossowski, Szymon, Pollock, Jonathan, Miao, Hongzhi, Linhares, Brian M., Kempinska, Katarzyna, Jin, Zhuang, Purohit, Trupta, Wen, Bo, He, Miao, Sun, Duxin, Cierpicki, Tomasz, Grembecka, Jolanta
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7029623/
https://ncbi.nlm.nih.gov/pubmed/29738674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00071
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