Pharmacologic inhibition of the menin-MLL interaction blocks progression of MLL leukemia in vivo

Chromosomal translocations affecting Mixed Lineage Leukemia gene (MLL) result in acute leukemias resistant to therapy. The leukemogenic activity of MLL fusion proteins is dependent on their interaction with menin, providing basis for therapeutic intervention. Here we report development of highly pot...

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Publicado no:Cancer Cell
Main Authors: Borkin, Dmitry, He, Shihan, Miao, Hongzhi, Kempinska, Katarzyna, Pollock, Jonathan, Chase, Jennifer, Purohit, Trupta, Malik, Bhavna, Zhao, Ting, Wang, Jingya, Wen, Bo, Zong, Hongliang, Jones, Morgan, Danet-Desnoyers, Gwenn, Guzman, Monica L., Talpaz, Moshe, Bixby, Dale L., Sun, Duxin, Hess, Jay L., Muntean, Andrew G., Maillard, Ivan, Cierpicki, Tomasz, Grembecka, Jolanta
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4415852/
https://ncbi.nlm.nih.gov/pubmed/25817203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.02.016
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