Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia

Menin functions as a critical oncogenic cofactor of mixed lineage leukemia (MLL) fusion proteins in the development of acute leukemias, and inhibition of the menin interaction with MLL fusion proteins represents a very promising strategy to reverse their oncogenic activity. MLL interacts with menin...

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Main Authors: Shi, Aibin, Murai, Marcelo J., He, Shihan, Lund, George, Hartley, Thomas, Purohit, Trupta, Reddy, Gireesh, Chruszcz, Maksymilian, Grembecka, Jolanta, Cierpicki, Tomasz
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2012
Assuntos:
Plenary Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3512226/
https://ncbi.nlm.nih.gov/pubmed/22936661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-05-429274
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