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Crystal Structure of Menin Reveals Binding Site for Mixed Lineage Leukemia (MLL) Protein
Menin is a tumor suppressor protein that is encoded by the MEN1 (multiple endocrine neoplasia 1) gene and controls cell growth in endocrine tissues. Importantly, menin also serves as a critical oncogenic cofactor of MLL (mixed lineage leukemia) fusion proteins in acute leukemias. Direct association...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3173070/ https://ncbi.nlm.nih.gov/pubmed/21757704 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.258186 |
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