Crystal Structure of Menin Reveals Binding Site for Mixed Lineage Leukemia (MLL) Protein

Menin is a tumor suppressor protein that is encoded by the MEN1 (multiple endocrine neoplasia 1) gene and controls cell growth in endocrine tissues. Importantly, menin also serves as a critical oncogenic cofactor of MLL (mixed lineage leukemia) fusion proteins in acute leukemias. Direct association...

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Bibliografske podrobnosti
Main Authors: Murai, Marcelo J., Chruszcz, Maksymilian, Reddy, Gireesh, Grembecka, Jolanta, Cierpicki, Tomasz
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Protein Structure and Folding
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173070/
https://ncbi.nlm.nih.gov/pubmed/21757704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.258186
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