High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein–Protein Interaction

[Image: see text] The protein–protein interaction (PPI) between menin and mixed lineage leukemia (MLL) plays a critical role in acute leukemias, and inhibition of this interaction represents a new potential therapeutic strategy for MLL leukemias. We report development of a novel class of small-molec...

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Detalhes bibliográficos
Main Authors: He, Shihan, Senter, Timothy J., Pollock, Jonathan, Han, Changho, Upadhyay, Sunil Kumar, Purohit, Trupta, Gogliotti, Rocco D., Lindsley, Craig W., Cierpicki, Tomasz, Stauffer, Shaun R., Grembecka, Jolanta
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983337/
https://ncbi.nlm.nih.gov/pubmed/24472025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401868d
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