Fusion partner–specific mutation profiles and KRAS mutations as adverse prognostic factors in MLL-rearranged AML

Mixed-lineage leukemia (MLL) gene rearrangements are among the most frequent chromosomal abnormalities in acute myeloid leukemia (AML). MLL fusion patterns are associated with the patient’s prognosis; however, their relationship with driver mutations is unclear. We conducted sequence analyses of 338...

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Vydáno v:Blood Adv
Hlavní autoři: Matsuo, Hidemasa, Yoshida, Kenichi, Nakatani, Kana, Harata, Yutarou, Higashitani, Moe, Ito, Yuri, Kamikubo, Yasuhiko, Shiozawa, Yusuke, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Okada, Ai, Nannya, Yasuhito, Takeda, June, Ueno, Hiroo, Kiyokawa, Nobutaka, Tomizawa, Daisuke, Taga, Takashi, Tawa, Akio, Miyano, Satoru, Meggendorfer, Manja, Haferlach, Claudia, Ogawa, Seishi, Adachi, Souichi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2020
Témata:
Myeloid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7556160/
https://ncbi.nlm.nih.gov/pubmed/32991719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020002457
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