An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model

Patients with a t(9;11) translocation (MLL-AF9) develop acute myeloid leukemia (AML), and while in mice the expression of this fusion oncogene also results in the development of myeloid leukemia, it is with long latency. To identify mutations that cooperate with Mll-AF9, we infected neonatal wild-ty...

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Hauptverfasser: Bergerson, Rachel J., Collier, Lara S., Sarver, Aaron L., Been, Raha A., Lugthart, Sanne, Diers, Miechaleen D., Zuber, Johannes, Rappaport, Amy R., Nixon, Molly J., Silverstein, Kevin A. T., Fan, Danhua, Lamblin, Anne-Francoise J., Wolff, Linda, Kersey, John H., Delwel, Ruud, Lowe, Scott W., O'Sullivan, M. Gerard, Kogan, Scott C., Adams, David J., Largaespada, David A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2012
Schlagworte:
Myeloid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362364/
https://ncbi.nlm.nih.gov/pubmed/22427200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-04-281428
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