An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model

Patients with a t(9;11) translocation (MLL-AF9) develop acute myeloid leukemia (AML), and while in mice the expression of this fusion oncogene also results in the development of myeloid leukemia, it is with long latency. To identify mutations that cooperate with Mll-AF9, we infected neonatal wild-ty...

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Détails bibliographiques
Auteurs principaux: Bergerson, Rachel J., Collier, Lara S., Sarver, Aaron L., Been, Raha A., Lugthart, Sanne, Diers, Miechaleen D., Zuber, Johannes, Rappaport, Amy R., Nixon, Molly J., Silverstein, Kevin A. T., Fan, Danhua, Lamblin, Anne-Francoise J., Wolff, Linda, Kersey, John H., Delwel, Ruud, Lowe, Scott W., O'Sullivan, M. Gerard, Kogan, Scott C., Adams, David J., Largaespada, David A.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2012
Sujets:
Myeloid Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362364/
https://ncbi.nlm.nih.gov/pubmed/22427200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-04-281428
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