NUP98-Fusion Proteins Interact With the NSL and MLL1 Complexes To Drive Leukemogenesis

The Nucleoporin 98 gene (NUP98) is fused to a variety of partner genes in multiple hematopoietic malignancies. Here we demonstrate that NUP98 fusion proteins, including NUP98-HOXA9 (NHA9), NUP98-HOXD13 (NHD13), NUP98-NSD1, NUP98-PHF23, and NUP98-TOP1 physically interact with mixed lineage leukemia 1...

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Bibliografiske detaljer
Udgivet i:	Cancer Cell
Main Authors:	Xu, Haiming, Valerio, Daria G, Eisold, Meghan E, Sinha, Amit, Koche, Richard P, Hu, Wenhuo, Chen, Chun-Wei, Chu, S Haihua, Brien, Gerard L, Park, Christopher Y., Hsieh, James J., Ernst, Patricia, Armstrong, Scott A
Format:	Artigo
Sprog:	Inglês
Udgivet:	2016
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5501282/ https://ncbi.nlm.nih.gov/pubmed/27889185 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.10.019
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NUP98-Fusion Proteins Interact With the NSL and MLL1 Complexes To Drive Leukemogenesis

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