Modeling de novo leukemogenesis from human cord blood with MN1 and NUP98HOXD13

Leukemic transformation of human cells is a complex process. Here we show that forced expression of MN1 in primitive human cord blood cells maintained on stromal cells in vitro induces a transient, but not serially transplantable, myeloproliferation in engrafted mice. However, cotransduction of an a...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Imren, Suzan, Heuser, Michael, Gasparetto, Maura, Beer, Philip A., Norddahl, Gudmundur L., Xiang, Ping, Chen, Ling, Berg, Tobias, Rhyasen, Garrett W., Rosten, Patricia, Park, Gyeongsin, Moon, Yeonsook, Weng, Andrew P., Eaves, Connie J., Humphries, R. Keith
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256911/
https://ncbi.nlm.nih.gov/pubmed/25339361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-04-564666
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