Loss of p53 accelerates the complications of myelodysplastic syndrome in a NUP98-HOXD13–driven mouse model

The nucleoporin gene NUP98 is fused to several genes including HOXD13 in patients with myelodysplastic syndromes (MDS), acute myeloid leukemia, and chronic myeloid leukemia, blast crisis. Genetically engineered mice that express a NUP98-HOXD13 (NHD13) transgene (Tg) display the phenotypic features o...

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Huvudupphovsmän: Xu, Haiming, Menendez, Silvia, Schlegelberger, Brigitte, Bae, Narae, Aplan, Peter D., Göhring, Gudrun, Deblasio, Tony R., Nimer, Stephen D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Hematology 2012
Ämnen:
Myeloid Neoplasia
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471517/
https://ncbi.nlm.nih.gov/pubmed/22927245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-405332
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