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Loss of p53 accelerates the complications of myelodysplastic syndrome in a NUP98-HOXD13–driven mouse model

The nucleoporin gene NUP98 is fused to several genes including HOXD13 in patients with myelodysplastic syndromes (MDS), acute myeloid leukemia, and chronic myeloid leukemia, blast crisis. Genetically engineered mice that express a NUP98-HOXD13 (NHD13) transgene (Tg) display the phenotypic features o...

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書誌詳細
主要な著者: Xu, Haiming, Menendez, Silvia, Schlegelberger, Brigitte, Bae, Narae, Aplan, Peter D., Göhring, Gudrun, Deblasio, Tony R., Nimer, Stephen D.
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Hematology 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471517/
https://ncbi.nlm.nih.gov/pubmed/22927245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-405332
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