Loss of p53 accelerates the complications of myelodysplastic syndrome in a NUP98-HOXD13–driven mouse model

The nucleoporin gene NUP98 is fused to several genes including HOXD13 in patients with myelodysplastic syndromes (MDS), acute myeloid leukemia, and chronic myeloid leukemia, blast crisis. Genetically engineered mice that express a NUP98-HOXD13 (NHD13) transgene (Tg) display the phenotypic features o...

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Autors principals: Xu, Haiming, Menendez, Silvia, Schlegelberger, Brigitte, Bae, Narae, Aplan, Peter D., Göhring, Gudrun, Deblasio, Tony R., Nimer, Stephen D.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2012
Matèries:
Myeloid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471517/
https://ncbi.nlm.nih.gov/pubmed/22927245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-405332
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