Loss of p53 accelerates the complications of myelodysplastic syndrome in a NUP98-HOXD13–driven mouse model

The nucleoporin gene NUP98 is fused to several genes including HOXD13 in patients with myelodysplastic syndromes (MDS), acute myeloid leukemia, and chronic myeloid leukemia, blast crisis. Genetically engineered mice that express a NUP98-HOXD13 (NHD13) transgene (Tg) display the phenotypic features o...

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Detalhes bibliográficos
Main Authors: Xu, Haiming, Menendez, Silvia, Schlegelberger, Brigitte, Bae, Narae, Aplan, Peter D., Göhring, Gudrun, Deblasio, Tony R., Nimer, Stephen D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471517/
https://ncbi.nlm.nih.gov/pubmed/22927245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-405332
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