Hematopoietic differentiation is required for initiation of acute myeloid leukemia

Mutations in acute myeloid leukemia (AML)-associated oncogenes often arise in hematopoietic stem cells (HSCs) and promote acquisition of leukemia stem cell (LSC) phenotypes. However, as LSCs often share features of lineage-restricted progenitors, the relative contribution of differentiation status t...

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Veröffentlicht in:Cell Stem Cell
Hauptverfasser: Ye, Min, Zhang, Hong, Yang, Henry, Koche, Richard, Staber, Philipp B., Cusan, Monica, Levantini, Elena, Welner, Robert S., Bach, Christian S., Zhang, Junyan, Krivtsov, Andrei, Armstrong, Scott A., Tenen, Daniel G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636971/
https://ncbi.nlm.nih.gov/pubmed/26412561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.08.011
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