Peptidomimetic blockade of MYB in acute myeloid leukemia

Aberrant gene expression is a hallmark of acute leukemias. MYB-driven transcriptional coactivation with CREB-binding protein (CBP)/P300 is required for acute lymphoblastic and myeloid leukemias, including refractory MLL-rearranged leukemias. Using structure-guided molecular design, we developed a pe...

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Publicat a:Nat Commun
Autors principals: Ramaswamy, Kavitha, Forbes, Lauren, Minuesa, Gerard, Gindin, Tatyana, Brown, Fiona, Kharas, Michael G., Krivtsov, Andrei V., Armstrong, Scott A., Still, Eric, de Stanchina, Elisa, Knoechel, Birgit, Koche, Richard, Kentsis, Alex
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760651/
https://ncbi.nlm.nih.gov/pubmed/29317678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02618-6
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