Sox4 is a key oncogenic target in C/EBPα mutant Acute Myeloid Leukemia

Mutation or epigenetic silencing of the transcription factor C/EBPα is observed in ~10% of patients with acute myeloid leukemia (AML). In both cases, a common global gene expression profile is observed, but down-stream targets relevant for leukemogenesis are not known. Here we identify Sox4 as a dir...

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Detalhes bibliográficos
Main Authors: Zhang, Hong, Alberich-Jordà, Meritxell, Amabile, Giovanni, Yang, Henry, Staber, Philipp B., DiRuscio, Annalisa, Welner, Rob, Ebralidze, Alexander, Zhang, Junyan, Levantini, Elena, Lefebvre, Véronique, Valk, Peter J.M., Delwel, Ruud, Hoogenkamp, Maarten, Nerlov, Claus, Cammenga, Jörg, Saez, Borja, Scadden, David T., Bonifer, Constanze, Ye, Min, Tenen, Daniel G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038627/
https://ncbi.nlm.nih.gov/pubmed/24183681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.09.018
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