Sox4 is a key oncogenic target in C/EBPα mutant Acute Myeloid Leukemia

Mutation or epigenetic silencing of the transcription factor C/EBPα is observed in ~10% of patients with acute myeloid leukemia (AML). In both cases, a common global gene expression profile is observed, but down-stream targets relevant for leukemogenesis are not known. Here we identify Sox4 as a dir...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Zhang, Hong, Alberich-Jordà, Meritxell, Amabile, Giovanni, Yang, Henry, Staber, Philipp B., DiRuscio, Annalisa, Welner, Rob, Ebralidze, Alexander, Zhang, Junyan, Levantini, Elena, Lefebvre, Véronique, Valk, Peter J.M., Delwel, Ruud, Hoogenkamp, Maarten, Nerlov, Claus, Cammenga, Jörg, Saez, Borja, Scadden, David T., Bonifer, Constanze, Ye, Min, Tenen, Daniel G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038627/
https://ncbi.nlm.nih.gov/pubmed/24183681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.09.018
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