Inhibition of MEK and ATR is effective in a B-cell acute lymphoblastic leukemia model driven by Mll-Af4 and activated Ras

Infant B-cell acute lymphoblastic leukemias (B-ALLs) that harbor MLL-AF4 rearrangements are associated with a poor prognosis. One important obstacle to progress for this patient population is the lack of immunocompetent models that faithfully recapitulate the short latency and aggressiveness of this...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Chu, S. Haihua, Song, Evelyn J., Chabon, Jonathan R., Minehart, Janna, Matovina, Chloe N., Makofske, Jessica L., Frank, Elizabeth S., Ross, Kenneth, Koche, Richard P., Feng, Zhaohui, Xu, Haiming, Krivtsov, Andrei, Nussenzweig, Andre, Armstrong, Scott A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177652/
https://ncbi.nlm.nih.gov/pubmed/30266823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018021592
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