Inhibition of MEK and ATR is effective in a B-cell acute lymphoblastic leukemia model driven by Mll-Af4 and activated Ras

Infant B-cell acute lymphoblastic leukemias (B-ALLs) that harbor MLL-AF4 rearrangements are associated with a poor prognosis. One important obstacle to progress for this patient population is the lack of immunocompetent models that faithfully recapitulate the short latency and aggressiveness of this...

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Detaylı Bibliyografya
Yayımlandı:Blood Adv
Asıl Yazarlar: Chu, S. Haihua, Song, Evelyn J., Chabon, Jonathan R., Minehart, Janna, Matovina, Chloe N., Makofske, Jessica L., Frank, Elizabeth S., Ross, Kenneth, Koche, Richard P., Feng, Zhaohui, Xu, Haiming, Krivtsov, Andrei, Nussenzweig, Andre, Armstrong, Scott A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2018
Konular:
Lymphoid Neoplasia
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177652/
https://ncbi.nlm.nih.gov/pubmed/30266823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018021592
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