A JAK/STAT-mediated inflammatory signaling cascade drives oncogenesis in AF10-rearranged AML

Leukemias bearing fusions of the AF10/MLLT10 gene are associated with poor prognosis, and therapies targeting these fusion proteins (FPs) are lacking. To understand mechanisms underlying AF10 fusion-mediated leukemogenesis, we generated inducible mouse models of acute myeloid leukemia (AML) driven b...

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Bibliographic Details
Published in:Blood
Main Authors: Chen, Bo-Rui, Deshpande, Anagha, Barbosa, Karina, Kleppe, Maria, Lei, Xue, Yeddula, Narayana, Vela, Pablo Sánchez, Campos, Alexandre Rosa, Wechsler-Reya, Robert J., Bagchi, Anindya, Meshinchi, Soheil, Eaves, Connie, Jeremias, Irmela, Haferlach, Torsten, Frank, David A., Ronai, Ze’ev, Chanda, Sumit, Armstrong, Scott A., Adams, Peter D., Levine, Ross L., Deshpande, Aniruddha J.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2021
Subjects:
Myeloid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8212510/
https://ncbi.nlm.nih.gov/pubmed/33690798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020009023
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