A JAK/STAT-mediated inflammatory signaling cascade drives oncogenesis in AF10-rearranged AML

Leukemias bearing fusions of the AF10/MLLT10 gene are associated with poor prognosis, and therapies targeting these fusion proteins (FPs) are lacking. To understand mechanisms underlying AF10 fusion-mediated leukemogenesis, we generated inducible mouse models of acute myeloid leukemia (AML) driven b...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Chen, Bo-Rui, Deshpande, Anagha, Barbosa, Karina, Kleppe, Maria, Lei, Xue, Yeddula, Narayana, Vela, Pablo Sánchez, Campos, Alexandre Rosa, Wechsler-Reya, Robert J., Bagchi, Anindya, Meshinchi, Soheil, Eaves, Connie, Jeremias, Irmela, Haferlach, Torsten, Frank, David A., Ronai, Ze’ev, Chanda, Sumit, Armstrong, Scott A., Adams, Peter D., Levine, Ross L., Deshpande, Aniruddha J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2021
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8212510/
https://ncbi.nlm.nih.gov/pubmed/33690798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020009023
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