The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations

Chromosomal translocations of the AF10 (or MLLT10) gene are frequently found in acute leukemias. Here, we show that the PZP domain of AF10 (AF10(PZP)), which is consistently impaired or deleted in leukemogenic AF10 translocations, plays a critical role in blocking malignant transformation. Incorpora...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Klein, Brianna J., Deshpande, Anagha, Cox, Khan L., Xuan, Fan, Zandian, Mohamad, Barbosa, Karina, Khanal, Sujita, Tong, Qiong, Zhang, Yi, Zhang, Pan, Sinha, Amit, Bohlander, Stefan K., Shi, Xiaobing, Wen, Hong, Poirier, Michael G., Deshpande, Aniruddha J., Kutateladze, Tatiana G.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8257627/
https://ncbi.nlm.nih.gov/pubmed/34226546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24418-9
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