The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations

Chromosomal translocations of the AF10 (or MLLT10) gene are frequently found in acute leukemias. Here, we show that the PZP domain of AF10 (AF10(PZP)), which is consistently impaired or deleted in leukemogenic AF10 translocations, plays a critical role in blocking malignant transformation. Incorpora...

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Publicat a:Nat Commun
Autors principals: Klein, Brianna J., Deshpande, Anagha, Cox, Khan L., Xuan, Fan, Zandian, Mohamad, Barbosa, Karina, Khanal, Sujita, Tong, Qiong, Zhang, Yi, Zhang, Pan, Sinha, Amit, Bohlander, Stefan K., Shi, Xiaobing, Wen, Hong, Poirier, Michael G., Deshpande, Aniruddha J., Kutateladze, Tatiana G.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8257627/
https://ncbi.nlm.nih.gov/pubmed/34226546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24418-9
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