Bivalent interaction of the PZP domain of BRPF1 with the nucleosome impacts chromatin dynamics and acetylation

BRPF1 (bromodomain PHD finger 1) is a core subunit of the MOZ histone acetyltransferase (HAT) complex, critical for normal developmental programs and implicated in acute leukemias. BRPF1 contains a unique assembly of zinc fingers, termed a PZP domain, the physiological role of which remains unclear....

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Klein, Brianna J., Muthurajan, Uma M., Lalonde, Marie-Eve, Gibson, Matthew D., Andrews, Forest H., Hepler, Maggie, Machida, Shinichi, Yan, Kezhi, Kurumizaka, Hitoshi, Poirier, Michael G., Côté, Jacques, Luger, Karolin, Kutateladze, Tatiana G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2016
Témata:
Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705663/
https://ncbi.nlm.nih.gov/pubmed/26626149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1321
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