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HPF1 and nucleosomes mediate a dramatic switch in activity of PARP1 from polymerase to hydrolase
Poly(ADP-ribose) polymerase 1 (PARP1) is an important player in the response to DNA damage. Recently, Histone PARylation Factor (HPF1) was shown to be a critical modulator of the activity of PARP1 by facilitating PARylation of histones and redirecting the target amino acid specificity from acidic to...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8012059/ https://ncbi.nlm.nih.gov/pubmed/33683197 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.65773 |
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