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Poly(ADP-ribose) polymerase 1 searches DNA via a ‘monkey bar’ mechanism
Poly(ADP-ribose) polymerase 1 (PARP1) is both a first responder to DNA damage and a chromatin architectural protein. How PARP1 rapidly finds DNA damage sites in the context of a nucleus filled with undamaged DNA, to which it also binds, is an unresolved question. Here, we show that PARP1 association...
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| Pubblicato in: | eLife |
|---|---|
| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications, Ltd
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6135609/ https://ncbi.nlm.nih.gov/pubmed/30088474 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.37818 |
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