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Novel modulators of poly(ADP-ribose) polymerase
The nuclear enzyme poly(ADP-ribose) polymerase (PARP)-1 has an important role in regulating cell death and cellular responses to DNA repair. Pharmacological inhibitors of PARP have entered clinical testing as cytoprotective agents in cardiovascular diseases and as adjunct antitumor therapeutics. Ini...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2228253/ https://ncbi.nlm.nih.gov/pubmed/17055069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tips.2006.10.003 |
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