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Role of Poly(ADP-Ribose) Polymerase-1 Activation in the Pathogenesis of Diabetic Complications: Endothelial Dysfunction, as a Common Underlying Theme

Hyperglycemia-induced overproduction of superoxide by mitochondrial electron-transport chain triggers several pathways of injury involved in the pathogenesis of diabetic complications [protein kinase C (PKC), hexosamine and polyol pathway fluxes, advanced glycation end product (AGE) formation] by in...

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Detalhes bibliográficos
Main Authors: PACHER, PÁL, SZABÓ, CSABA
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2228261/
https://ncbi.nlm.nih.gov/pubmed/16356120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2005.7.1568
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