Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1

Poly(ADP-ribose) Polymerase 2 (PARP2) is one of three DNA-dependent PARPs involved in the detection of DNA damage. Upon binding to DNA double-strand breaks, PARP2 uses nicotinamide adenine dinucleotide to synthesize poly(ADP-ribose) (PAR) onto itself and other proteins, including histones. PAR chain...

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Vydáno v:PLoS One
Hlavní autoři: Gaullier, Guillaume, Roberts, Genevieve, Muthurajan, Uma M., Bowerman, Samuel, Rudolph, Johannes, Mahadevan, Jyothi, Jha, Asmita, Rae, Purushka S., Luger, Karolin
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7608914/
https://ncbi.nlm.nih.gov/pubmed/33141820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0240932
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