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Histone Parylation factor 1 contributes to the inhibition of PARP1 by cancer drugs
Poly-(ADP-ribose) polymerase 1 and 2 (PARP1 and PARP2) are key enzymes in the DNA damage response. Four different inhibitors (PARPi) are currently in the clinic for treatment of ovarian and breast cancer. Recently, histone PARylation Factor 1 (HPF1) has been shown to play an essential role in the PA...
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| Publicado en: | Nat Commun |
|---|---|
| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7854685/ https://ncbi.nlm.nih.gov/pubmed/33531508 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-20998-8 |
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