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An Interaction with PARP-1 and Inhibition of Parylation Contribute to Attenuation of DNA Damage Signaling by the Adenovirus E4orf4 Protein

The adenovirus (Ad) E4orf4 protein was reported to contribute to inhibition of ATM- and ATR-regulated DNA damage signaling during Ad infection and following treatment with DNA-damaging drugs. Inhibition of these pathways improved Ad replication, and when expressed alone, E4orf4 sensitized transforme...

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Bibliografische gegevens
Gepubliceerd in:J Virol
Hoofdauteurs: Nebenzahl-Sharon, Keren, Sharf, Rakefet, Amer, Jana, Shalata, Hassan, Khoury-Haddad, Hanan, Sohn, Sook-Young, Ayoub, Nabieh, Hearing, Patrick, Kleinberger, Tamar
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744226/
https://ncbi.nlm.nih.gov/pubmed/31315986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02253-18
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