Biphasic Functional Interaction between the Adenovirus E4orf4 Protein and DNA-PK

The adenovirus (Ad) E4orf4 protein contributes to virus-induced inhibition of the DNA damage response (DDR) by reducing ATM and ATR signaling. Consequently, E4orf4 inhibits DNA repair and sensitizes transformed cells to killing by DNA-damaging drugs. Inhibition of ATM and ATR signaling contributes t...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Nebenzahl-Sharon, Keren, Shalata, Hassan, Sharf, Rakefet, Amer, Jana, Khoury-Haddad, Hanan, Sohn, Sook-Young, Ayoub, Nabieh, Hearing, Patrick, Kleinberger, Tamar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6498064/
https://ncbi.nlm.nih.gov/pubmed/30842317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01365-18
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