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Biphasic Functional Interaction between the Adenovirus E4orf4 Protein and DNA-PK
The adenovirus (Ad) E4orf4 protein contributes to virus-induced inhibition of the DNA damage response (DDR) by reducing ATM and ATR signaling. Consequently, E4orf4 inhibits DNA repair and sensitizes transformed cells to killing by DNA-damaging drugs. Inhibition of ATM and ATR signaling contributes t...
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| Udgivet i: | J Virol |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6498064/ https://ncbi.nlm.nih.gov/pubmed/30842317 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01365-18 |
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