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Automodification switches PARP-1 function from chromatin architectural protein to histone chaperone
Poly [ADP-ribose] polymerase 1 (PARP-1) is a highly abundant chromatin-associated enzyme. It catalyzes the NAD(+)-dependent polymerization of long chains of poly-ADP ribose (PAR) onto itself in response to DNA damage and other cues. More recently, the enzymatic activity of PARP-1 has also been impli...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4156740/ https://ncbi.nlm.nih.gov/pubmed/25136112 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1405005111 |
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