Automodification switches PARP-1 function from chromatin architectural protein to histone chaperone

Poly [ADP-ribose] polymerase 1 (PARP-1) is a highly abundant chromatin-associated enzyme. It catalyzes the NAD(+)-dependent polymerization of long chains of poly-ADP ribose (PAR) onto itself in response to DNA damage and other cues. More recently, the enzymatic activity of PARP-1 has also been impli...

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Bibliografske podrobnosti
Main Authors: Muthurajan, Uma M., Hepler, Maggie R. D., Hieb, Aaron R., Clark, Nicholas J., Kramer, Michael, Yao, Tingting, Luger, Karolin
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2014
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156740/
https://ncbi.nlm.nih.gov/pubmed/25136112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1405005111
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