The PZP domain of AF10 senses unmodified H3K27 to regulate DOT1L-mediated methylation of H3K79

AF10, a DOT1L cofactor, is required for H3K79 methylation and cooperates with DOT1L in leukemogenesis. However, the molecular mechanism by which AF10 regulates DOT1L-mediated H3K79 methylation is not clear. Here, we report that AF10 contains a “reader” domain that couples unmodified H3K27 recognitio...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Chen, Shoudeng, Yang, Ze, Wilkinson, Alex W., Deshpande, Aniruddha J., Sidoli, Simone, Krajewski, Krzysztof, Strahl, Brian D., Garcia, Benjamin A., Armstrong, Scott A., Patel, Dinshaw J., Gozani, Or
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4609290/
https://ncbi.nlm.nih.gov/pubmed/26439302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.08.019
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