A JAK/STAT-mediated inflammatory signaling cascade drives oncogenesis in AF10-rearranged AML

Leukemias bearing fusions of the AF10/MLLT10 gene are associated with poor prognosis, and therapies targeting these fusion proteins (FPs) are lacking. To understand mechanisms underlying AF10 fusion-mediated leukemogenesis, we generated inducible mouse models of acute myeloid leukemia (AML) driven b...

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Détails bibliographiques
Publié dans:Blood
Auteurs principaux: Chen, Bo-Rui, Deshpande, Anagha, Barbosa, Karina, Kleppe, Maria, Lei, Xue, Yeddula, Narayana, Vela, Pablo Sánchez, Campos, Alexandre Rosa, Wechsler-Reya, Robert J., Bagchi, Anindya, Meshinchi, Soheil, Eaves, Connie, Jeremias, Irmela, Haferlach, Torsten, Frank, David A., Ronai, Ze’ev, Chanda, Sumit, Armstrong, Scott A., Adams, Peter D., Levine, Ross L., Deshpande, Aniruddha J.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2021
Sujets:
Myeloid Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8212510/
https://ncbi.nlm.nih.gov/pubmed/33690798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020009023
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