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A CALM-derived nuclear export signal is essential for CALM-AF10–mediated leukemogenesis

The t(10;11) chromosomal translocation gives rise to the CALM-AF10 fusion gene and is found in patients with aggressive and difficult-to-treat hematopoietic malignancies. CALM-AF10–driven leukemias are characterized by HOXA gene up-regulation and a global reduction in H3K79 methylation. DOT1L, the H...

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Autors principals: Conway, Amanda E., Scotland, Paula B., Lavau, Catherine P., Wechsler, Daniel S.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674674/
https://ncbi.nlm.nih.gov/pubmed/23487024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-06-435792
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