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A CALM-derived nuclear export signal is essential for CALM-AF10–mediated leukemogenesis
The t(10;11) chromosomal translocation gives rise to the CALM-AF10 fusion gene and is found in patients with aggressive and difficult-to-treat hematopoietic malignancies. CALM-AF10–driven leukemias are characterized by HOXA gene up-regulation and a global reduction in H3K79 methylation. DOT1L, the H...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society of Hematology
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3674674/ https://ncbi.nlm.nih.gov/pubmed/23487024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-06-435792 |
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