A JAK/STAT-mediated inflammatory signaling cascade drives oncogenesis in AF10-rearranged AML

Leukemias bearing fusions of the AF10/MLLT10 gene are associated with poor prognosis, and therapies targeting these fusion proteins (FPs) are lacking. To understand mechanisms underlying AF10 fusion-mediated leukemogenesis, we generated inducible mouse models of acute myeloid leukemia (AML) driven b...

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Bibliografiske detaljer
Udgivet i:Blood
Main Authors: Chen, Bo-Rui, Deshpande, Anagha, Barbosa, Karina, Kleppe, Maria, Lei, Xue, Yeddula, Narayana, Vela, Pablo Sánchez, Campos, Alexandre Rosa, Wechsler-Reya, Robert J., Bagchi, Anindya, Meshinchi, Soheil, Eaves, Connie, Jeremias, Irmela, Haferlach, Torsten, Frank, David A., Ronai, Ze’ev, Chanda, Sumit, Armstrong, Scott A., Adams, Peter D., Levine, Ross L., Deshpande, Aniruddha J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2021
Fag:
Myeloid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8212510/
https://ncbi.nlm.nih.gov/pubmed/33690798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020009023
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