Specific patterns of H3K79 methylation influence genetic interaction of oncogenes in AML

Understanding mechanisms of cooperation between oncogenes is critical for the development of novel therapies and rational combinations. Acute myeloid leukemia (AML) cells with KMT2A-fusions and KMT2A partial tandem duplications (KMT2A(PTD)) are known to depend on the histone methyltransferase DOT1L,...

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Veröffentlicht in:Blood Adv
Hauptverfasser: Kingsley, Molly C., Xie, Hongbo M., Chen, Bo-Rui, Riedel, Simone S., Pastuer, Taylor, Bollig, Madelyn K., Shank, Tyler, Libbrecht, Clara, Stabler, Sally P., Deshpande, Aniruddha J., Intlekofer, Andrew M., Bernt, Kathrin M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2020
Schlagworte:
Myeloid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7362367/
https://ncbi.nlm.nih.gov/pubmed/32634241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020001922
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