Specific patterns of H3K79 methylation influence genetic interaction of oncogenes in AML

Understanding mechanisms of cooperation between oncogenes is critical for the development of novel therapies and rational combinations. Acute myeloid leukemia (AML) cells with KMT2A-fusions and KMT2A partial tandem duplications (KMT2A(PTD)) are known to depend on the histone methyltransferase DOT1L,...

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Pubblicato in:Blood Adv
Autori principali: Kingsley, Molly C., Xie, Hongbo M., Chen, Bo-Rui, Riedel, Simone S., Pastuer, Taylor, Bollig, Madelyn K., Shank, Tyler, Libbrecht, Clara, Stabler, Sally P., Deshpande, Aniruddha J., Intlekofer, Andrew M., Bernt, Kathrin M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2020
Soggetti:
Myeloid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7362367/
https://ncbi.nlm.nih.gov/pubmed/32634241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020001922
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