Essential role of PR-domain protein MDS1-EVI1 in MLL-AF9 leukemia

A subgroup of leukemogenic mixed-lineage leukemia (MLL) fusion proteins (MFPs) including MLL-AF9 activates the Mecom locus and exhibits extremely poor clinical prognosis. Mecom encodes EVI1 and MDS1-EVI1 (ME) proteins via alternative transcription start sites; these differ by the presence of a PRDI-...

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Main Authors: Zhang, Yi, Owens, Kristina, Hatem, Layla, Glass, Carolyn H., Karuppaiah, Kannan, Camargo, Fernando, Perkins, Archibald S.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2013
Teme:
Myeloid Neoplasia
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799001/
https://ncbi.nlm.nih.gov/pubmed/24021671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-08-453662
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