Differential role of Id1 in MLL-AF9–driven leukemia based on cell of origin

Inhibitor of DNA binding 1 (Id1) functions as an E protein inhibitor, and overexpression of Id1 is seen in acute myeloid leukemia (AML) patients. To define the effects of Id1 on leukemogenesis, we expressed MLL-AF9 in fetal liver (FL) cells or bone marrow (BM) cells isolated from wild-type, Id1(−/−)...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Man, Na, Sun, Xiao-Jian, Tan, Yurong, García-Cao, Marta, Liu, Fan, Cheng, Guoyan, Hatlen, Megan, Xu, Haiming, Shah, Ronit, Chastain, Nolan, Liu, Na, Huang, Gang, Zhou, Yuan, Sheng, Mengyao, Song, Junhong, Yang, Feng-Chun, Benezra, Robert, Nimer, Stephen D., Wang, Lan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865589/
https://ncbi.nlm.nih.gov/pubmed/26944543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-11-677708
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