miR-125b promotes MLL-AF9–driven murine acute myeloid leukemia involving a VEGFA-mediated non–cell-intrinsic mechanism

The hematopoietic stem cell–enriched miR-125 family microRNAs (miRNAs) are critical regulators of hematopoiesis. Overexpression of miR-125a or miR-125b is frequent in human acute myeloid leukemia (AML), and the overexpression of these miRNAs in mice leads to expansion of hematopoietic stem cells acc...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Liu, Jun, Guo, Bo, Chen, Zhuo, Wang, Nayi, Iacovino, Michelina, Cheng, Jijun, Roden, Christine, Pan, Wen, Khan, Sajid, Chen, Suning, Kyba, Michael, Fan, Rong, Guo, Shangqin, Lu, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356452/
https://ncbi.nlm.nih.gov/pubmed/28053194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-06-721027
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