Severe congenital neutropenia and chronic neutrophilic leukemia: an intriguing molecular connection unveiled by oncogenic mutations in CSF3R

Por Touw, Ivo P., Beekman, Renée
Publicado em 2013

Severe congenital neutropenias

Por Skokowa, Julia, Dale, David C., Touw, Ivo P., Zeidler, Cornelia, Welte, Karl
Publicado no Nat Rev Dis Primers (2017)

Prevalence of a new auto-activating colony stimulating factor 3 receptor mutation (CSF3R-T595I) in acute myeloid leukemia and severe congenital neutropenia

Por Beekman, Renée, Valkhof, Marijke, van Strien, Paulette, Valk, Peter J.M., Touw, Ivo P.
Publicado em 2013

Analysis of Jak2 Catalytic Function by Peptide Microarrays: The Role of the JH2 Domain and V617F Mutation

Por Sanz, Arturo, Ungureanu, Daniela, Pekkala, Tuija, Ruijtenbeek, Rob, Touw, Ivo P., Hilhorst, Riet, Silvennoinen, Olli
Publicado em 2011

Transcriptional Reprogramming of CD11b(+)Esam(hi) Dendritic Cell Identity and Function by Loss of Runx3

Por Dicken, Joseph, Mildner, Alexander, Leshkowitz, Dena, Touw, Ivo P., Hantisteanu, Shay, Jung, Steffen, Groner, Yoram
Publicado em 2013

Suppressor of cytokine signaling 3 controls lysosomal routing of G-CSF receptor

Por Irandoust, Mahban I, Aarts, Lambertus HJ, Roovers, Onno, Gits, Judith, Erkeland, Stefan J, Touw, Ivo P
Publicado em 2007

Suppressor of cytokine signaling 3 controls lysosomal routing of G-CSF receptor

Por Irandoust, Mahban I, Aarts, Lambertus H J, Roovers, Onno, Gits, Judith, Erkeland, Stefan J, Touw, Ivo P
Publicado em 2007

G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth

Por Zhu, Quan-sheng, Xia, Ling, Mills, Gordon B., Lowell, Clifford A., Touw, Ivo P., Corey, Seth J.
Publicado em 2006

Sustained Receptor Activation and Hyperproliferation in Response to Granulocyte Colony-stimulating Factor (G-CSF) in Mice with a Severe Congenital Neutropenia/Acute Myeloid Leukemi...

Por Hermans, Mirjam H.A., Antonissen, Claudia, Ward, Alister C., Mayen, Angelique E.M., Ploemacher, Rob E., Touw, Ivo P.
Publicado em 1999

The Antioxidant Protein Peroxiredoxin 4 Is Epigenetically Down Regulated in Acute Promyelocytic Leukemia

Por Palande, Karishma K., Beekman, Renee, van der Meeren, Lotte E., Beverloo, H. Berna, Valk, Peter J. M., Touw, Ivo P.
Publicado em 2011

Large-Scale Identification of Disease Genes Involved in Acute Myeloid Leukemia

Por Erkeland, Stefan J., Valkhof, Marijke, Heijmans-Antonissen, Claudia, van Hoven-Beijen, Antoinette, Delwel, Ruud, Hermans, Mirjam H. A., Touw, Ivo P.
Publicado em 2004

Reduced hematopoietic reserves in DNA interstrand crosslink repair-deficient Ercc1(−/−) mice

Por Prasher, Joanna M, Lalai, Astrid S, Heijmans-Antonissen, Claudia, Ploemacher, Robert E, Hoeijmakers, Jan H J, Touw, Ivo P, Niedernhofer, Laura J
Publicado em 2005

HAT: Hypergeometric Analysis of Tiling-arrays with application to promoter-GeneChip data

Por Taskesen, Erdogan, Beekman, Renee, de Ridder, Jeroen, Wouters, Bas J, Peeters, Justine K, Touw, Ivo P, Reinders, Marcel JT, Delwel, Ruud
Publicado em 2010

Loss of Ercc1 Results in a Time- and Dose-Dependent Reduction of Proliferating Early Hematopoietic Progenitors

Por Verhagen-Oldenampsen, Judith H. E., Haanstra, Jurgen R., van Strien, Paulina M. H., Valkhof, Marijke, Touw, Ivo P., von Lindern, Marieke
Publicado em 2012

Peroxiredoxin-controlled G-CSF signalling at the endoplasmic reticulum–early endosome interface

Por Palande, Karishma, Roovers, Onno, Gits, Judith, Verwijmeren, Carola, Iuchi, Yoshihito, Fujii, Junichi, Neel, Benjamin G., Karisch, Robert, Tavernier, Jan, Touw, Ivo P.
Publicado em 2011

Retroviral Integration Mutagenesis in Mice and Comparative Analysis in Human AML Identify Reduced PTP4A3 Expression as a Prognostic Indicator

Por Beekman, Renée, Valkhof, Marijke, Erkeland, Stefan J., Taskesen, Erdogan, Rockova, Veronika, Peeters, Justine K., Valk, Peter J. M., Löwenberg, Bob, Touw, Ivo P.
Publicado em 2011

Novel Point Mutation in the Extracellular Domain of the Granulocyte Colony-Stimulating Factor (G-Csf) Receptor in a Case of Severe Congenital Neutropenia Hyporesponsive to G-Csf Tr...

Por Ward, Alister C., van Aesch, Yvette M., Gits, Judith, Schelen, Anita M., de Koning, John P., van Leeuwen, Daphne, Freedman, Melvin H., Touw, Ivo P.
Publicado em 1999

Essential Role for Cyclin D3 in Granulocyte Colony-Stimulating Factor-Driven Expansion of Neutrophil Granulocytes

Por Sicinska, Ewa , Lee, Young-Mi, Gits, Judith, Shigematsu, Hirokazu, Yu, Qunyan, Rebel, Vivienne I., Geng, Yan, Marshall, Christopher J., Akashi, Koichi, Dorfman, David M., Touw, Ivo P., Sicinski, Piotr
Publicado em 2006

Classification of pediatric acute myeloid leukemia based on miRNA expression profiles

Por Obulkasim, Askar, Katsman-Kuipers, Jenny E., Verboon, Lonneke, Sanders, Mathijs, Touw, Ivo, Jongen-Lavrencic, Mojca, Pieters, Rob, Klusmann, Jan-Henning, Zwaan, C. Michel, van den Heuvel-Eibrink, Marry M., Fornerod, Maarten
Publicado no Oncotarget (2017)

Deficiency of the ribosome biogenesis gene Sbds in hematopoietic stem and progenitor cells causes neutropenia in mice by attenuating lineage progression in myelocytes

Por Zambetti, Noemi A., Bindels, Eric M. J., Van Strien, Paulina M. H., Valkhof, Marijke G., Adisty, Maria N., Hoogenboezem, Remco M., Sanders, Mathijs A., Rommens, Johanna M., Touw, Ivo P., Raaijmakers, Marc H. G. P.
Publicado no Haematologica (2015)