PML-controlled responses in severe congenital neutropenia with ELANE-misfolding mutations

Mutations in ELANE cause severe congenital neutropenia (SCN), but how they affect neutrophil production and contribute to leukemia predisposition is unknown. Neutropenia is alleviated by CSF3 (granulocyte colony-stimulating factor) therapy in most cases, but dose requirements vary between patients....

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Olofsen, Patricia A., Bosch, Dennis A., Roovers, Onno, van Strien, Paulina M. H., de Looper, Hans W. J., Hoogenboezem, Remco M., Barnhoorn, Sander, Mastroberardino, Pier G., Ghazvini, Mehrnaz, van der Velden, Vincent H. J., Bindels, Eric M. J., de Pater, Emma M., Touw, Ivo P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2021
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7876869/
https://ncbi.nlm.nih.gov/pubmed/33560392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020003214
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