Dynamic evolution of clonal epialleles revealed by methclone

We describe methclone, a novel method to identify epigenetic loci that harbor large changes in the clonality of their epialleles (epigenetic alleles). Methclone efficiently analyzes genome-wide DNA methylation sequencing data. We quantify the changes using a composition entropy difference calculatio...

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Dades bibliogràfiques
Publicat a:Genome Biol
Autors principals: Li, Sheng, Garrett-Bakelman, Francine, Perl, Alexander E, Luger, Selina M, Zhang, Chao, To, Bik L, Lewis, Ian D, Brown, Anna L, D’Andrea, Richard J, Ross, M Elizabeth, Levine, Ross, Carroll, Martin, Melnick, Ari, Mason, Christopher E
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2014
Matèries:
Method
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4242486/
https://ncbi.nlm.nih.gov/pubmed/25260792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0472-5
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