Loss of BAP1 function leads to EZH2-dependent transformation

BAP1 and ASXL1 interact to form a polycomb deubiquitinase complex that removes monoubiquitin from histone H2A lysine 119 (H2AK119Ub). However, BAP1 and ASXL1 are mutated in distinct cancer types, consistent with independent roles in regulating epigenetic state and malignant transformation. Here we d...

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Udgivet i:Nat Med
Main Authors: LaFave, Lindsay M., Béguelin, Wendy, Koche, Richard, Teater, Matt, Spitzer, Barbara, Chramiec, Alan, Papalexi, Efthymia, Keller, Matthew D., Hricik, Todd, Konstantinoff, Katerina, Micol, Jean-Baptiste, Durham, Benjamin, Knutson, Sarah K., Campbell, John E., Blum, Gil, Shi, Xinxu, Doud, Emma H., Krivtsov, Andrei V., Chung, Young Rock, Khodos, Inna, de Stanchina, Elisa, Ouerfelli, Ouathek, Adusumilli, Prasad S., Thomas, Paul M., Kelleher, Neil L., Luo, Minkui, Keilhack, Heike, Abdel-Wahab, Omar, Melnick, Ari, Armstrong, Scott A., Levine, Ross L.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636469/
https://ncbi.nlm.nih.gov/pubmed/26437366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3947
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