Selective inhibition of the citrate-to-isocitrate reaction of cytosolic aconitase by phosphomimetic mutation of serine-711

Por Pitula, Joseph S., Deck, Kathryn M., Clarke, Stephen L., Anderson, Sheila A., Vasanthakumar, Aparna, Eisenstein, Richard S.
Publicado em 2004

Evidence That Phosphorylation of Iron Regulatory Protein 1 at Serine 138 Destabilizes the [4Fe-4S] Cluster in Cytosolic Aconitase by Enhancing 4Fe-3Fe Cycling

Por Deck, Kathryn M., Vasanthakumar, Aparna, Anderson, Sheila A., Goforth, Jeremy B., Kennedy, M. Claire, Antholine, William E., Eisenstein, Richard S.
Publicado em 2009

Epigenetic control of Apolipoprotein E expression mediates gender-specific hematopoietic regulation

Por Vasanthakumar, Aparna, Zullow, Hayley, Lepore, Janet B., Thomas, Kenya, Young, Natalie, Anastasi, John, Reardon, Catherine A., Godley, Lucy A.
Publicado no Stem Cells (2015)

Iron-responsive degradation of iron-regulatory protein 1 does not require the Fe–S cluster

Por Clarke, Stephen L, Vasanthakumar, Aparna, Anderson, Sheila A, Pondarré, Corinne, Koh, Cheryl M, Deck, Kathryn M, Pitula, Joseph S, Epstein, Charles J, Fleming, Mark D, Eisenstein, Richard S
Publicado em 2006

Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia

Por Yamazaki, Jumpei, Taby, Rodolphe, Vasanthakumar, Aparna, Macrae, Trisha, Ostler, Kelly R, Shen, Lanlan, Kantarjian, Hagop M, Estecio, Marcos R, Jelinek, Jaroslav, Godley, Lucy A, Issa, Jean-Pierre J
Publicado em 2012

2-Hydroxyglutarate in IDH mutant acute myeloid leukemia: predicting patient responses, minimal residual disease and correlations with methylcytosine and hydroxymethylcytosine level...

Por Pollyea, Daniel A., Kohrt, Holbrook E., Zhang, Bing, Zehnder, James, Schenkein, David, Fantin, Valeria, Straley, Kimberly, Vasanthakumar, Aparna, Abdel-Wahab, Omar, Levine, Ross, Godley, Lucy A., Medeiros, Bruno C.
Publicado em 2012

Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis

Por Vasanthakumar, Aparna, Lepore, Janet B., Zegarek, Matthew H., Kocherginsky, Masha, Singh, Mahi, Davis, Elizabeth M., Link, Petra A., Anastasi, John, Le Beau, Michelle M., Karpf, Adam R., Godley, Lucy A.
Publicado em 2013

TET1-Mediated Hydroxymethylation Facilitates Hypoxic Gene Induction in Neuroblastoma

Por Mariani, Christopher J., Vasanthakumar, Aparna, Madzo, Jozef, Yesilkanal, Ali, Bhagat, Tushar, Yu, Yiting, Bhattacharyya, Sanchari, Wenger, Roland H., Cohn, Susan L., Nanduri, Jayasri, Verma, Amit, Prabhakar, Nanduri R., Godley, Lucy A.
Publicado no Cell Rep (2014)

DNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID

Por Dominguez, Pilar M., Teater, Matt, Chambwe, Nyasha, Kormaksson, Matthias, Redmond, David, Ishii, Jennifer, Vuong, Bao, Chaudhuri, Jayanta, Melnick, Ari, Vasanthakumar, Aparna, Godley, Lucy A., Papavasiliou, F Nina, Elemento, Olivier, Shaknovich, Rita
Publicado no Cell Rep (2015)

Genome-wide hydroxymethylation tested using the HELP-GT assay shows redistribution in cancer

Por Bhattacharyya, Sanchari, Yu, Yiting, Suzuki, Masako, Campbell, Nathaniel, Mazdo, Jozef, Vasanthakumar, Aparna, Bhagat, Tushar D., Nischal, Sangeeta, Christopeit, Maximilian, Parekh, Samir, Steidl, Ulrich, Godley, Lucy, Maitra, Anirban, Greally, John M., Verma, Amit
Publicado em 2013

Brca1 deficiency causes bone marrow failure and spontaneous hematologic malignancies in mice

Por Vasanthakumar, Aparna, Arnovitz, Stephen, Marquez, Rafael, Lepore, Janet, Rafidi, George, Asom, Anase, Weatherly, Madison, Davis, Elizabeth M., Neistadt, Barbara, Duszynski, Robert, Vardiman, James W., Le Beau, Michelle M., Godley, Lucy A., Churpek, Jane E.
Publicado no Blood (2016)

5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging

Por Szulwach, Keith E, Li, Xuekun, Li, Yujing, Song, Chun-Xiao, Wu, Hao, Dai, Qing, Irier, Hasan, Upadhyay, Anup K, Gearing, Marla, Levey, Allan I, Vasanthakumar, Aparna, Godley, Lucy A, Chang, Qiang, Cheng, Xiaodong, He, Chuan, Jin, Peng
Publicado em 2011

DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis

Por Shah, Mrinal Y., Vasanthakumar, Aparna, Barnes, Natalie Y., Figueroa, Maria E., Kamp, Anna, Hendrick, Christopher, Ostler, Kelly R., Davis, Elizabeth M., Lin, Shang, Anastasi, John, Le Beau, Michelle M., Moskowitz, Ivan, Melnick, Ari, Pytel, Peter, Godley, Lucy A.
Publicado em 2010

TET2 mutations affect non-CpG island DNA methylation at enhancers and transcription factor binding sites in chronic myelomonocytic leukemia

Por Yamazaki, Jumpei, Jelinek, Jaroslav, Lu, Yue, Cesaroni, Matteo, Madzo, Jozef, Neumann, Frank, He, Rong, Taby, Rodolphe, Vasanthakumar, Aparna, Macrae, Trisha, Ostler, Kelly R., Kantarjian, Hagop M., Liang, Shoudan, Estecio, Marcos R., Godley, Lucy A., Issa, Jean-Pierre J.
Publicado no Cancer Res (2015)

DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation

Por Shaknovich, Rita, Cerchietti, Leandro, Tsikitas, Lucas, Kormaksson, Matthias, De, Subhajyoti, Figueroa, Maria E., Ballon, Gianna, Yang, Shao Ning, Weinhold, Nils, Reimers, Mark, Clozel, Thomas, Luttrop, Karin, Ekstrom, Tomas J., Frank, Jared, Vasanthakumar, Aparna, Godley, Lucy A., Michor, Franziska, Elemento, Olivier, Melnick, Ari
Publicado em 2011

Dnmt3a is essential for hematopoietic stem cell differentiation

Por Challen, Grant A, Sun, Deqiang, Jeong, Mira, Luo, Min, Jelinek, Jaroslav, Berg, Jonathan S, Bock, Christoph, Vasanthakumar, Aparna, Gu, Hongcang, Xi, Yuanxin, Liang, Shoudan, Lu, Yue, Darlington, Gretchen J, Meissner, Alexander, Issa, Jean-Pierre J, Godley, Lucy A, Li, Wei, Goodell, Margaret A
Publicado em 2011

Truncated DNMT3B isoform DNMT3B7 suppresses growth, induces differentiation, and alters DNA methylation in human neuroblastoma

Por Ostler, Kelly R., Yang, Qiwei, Looney, Timothy J., Zhang, Li, Vasanthakumar, Aparna, Tian, Yufeng, Kocherginsky, Masha, Raimondi, Stacey L., DeMaio, Jessica G., Salwen, Helen R., Gu, Song, Chlenski, Alexandre, Naranjo, Arlene, Gill, Amy, Peddinti, Radhika, Lahn, Bruce T., Cohn, Susan L., Godley, Lucy A.
Publicado em 2012

Recurrent Somatic TET2 Mutations in Normal Elderly Individuals With Clonal Hematopoiesis

Por Busque, Lambert, Patel, Jay P., Figueroa, Maria, Vasanthakumar, Aparna, Provost, Sylvie, Hamilou, Zineb, Mollica, Luigina, Li, Juan, Viale, Agnes, Heguy, Adriana, Hassimi, Maryam, Socci, Nicholas, Bhatt, Parva K., Gonen, Mithat, Mason, Christopher E., Melnick, Ari, Godley, Lucy A., Brennan, Cameron, Abdel-Wahab, Omar, Levine, Ross L.
Publicado em 2012

Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors

Por Pronier, Elodie, Almire, Carole, Mokrani, Hayat, Vasanthakumar, Aparna, Simon, Audrey, da Costa Reis Monte Mor, Barbara, Massé, Aline, Le Couédic, Jean-Pierre, Pendino, Frédéric, Carbonne, Bruno, Larghero, Jérôme, Ravanat, Jean-Luc, Casadevall, Nicole, Bernard, Olivier A., Droin, Nathalie, Solary, Eric, Godley, Lucy A., Vainchenker, William, Plo, Isabelle, Delhommeau, François
Publicado em 2011

Mechanism-Based Epigenetic Chemosensitization Therapy of Diffuse Large B Cell Lymphoma

Por Clozel, Thomas, Yang, ShaoNing, Elstrom, Rebecca L., Tam, Wayne, Martin, Peter, Kormaksson, Matthias, Banerjee, Samprit, Vasanthakumar, Aparna, Culjkovic, Biljana, Scott, David W., Wyman, Sarah, Leser, Michael, Shaknovich, Rita, Chadburn, Amy, Tabbo, Fabrizio, Godley, Lucy A., Gascoyne, Randy D., Borden, Katherine L., Inghirami, Giorgio, Leonard, John P., Melnick, Ari, Cerchietti, Leandro
Publicado em 2013